Inflammatory biomarkers continue to play an increasingly important role in laboratory research, helping investigators better understand disease activity, treatment response, and the underlying biology of chronic inflammatory conditions. Among these biomarkers, calprotectin MRP8/14 has emerged as a valuable tool for studying inflammation across multiple disease areas. Its role in the inflammatory response and its applications across diverse research settings have made calprotectin MRP8/14 an important focus of inflammation research.
Calprotectin is a calcium- and zinc-binding protein complex composed of S100A8, also known as calgranulin A or MRP8, and S100A9, also known as calgranulin B or MRP14. The complex is highly abundant in neutrophils and is also expressed and released by monocytes during inflammatory responses.
Calprotectin has been associated with a wide range of inflammatory and immune-mediated diseases. Reflecting the broad biological role of the S100A8/S100A9 complex, elevated concentrations have been investigated in gastrointestinal, rheumatologic, dermatologic, respiratory, and other inflammatory conditions.
Because activated neutrophils and monocytes release S100A8/S100A9 during inflammation, calprotectin concentrations have been investigated as markers of innate immune activation and inflammatory activity across several research settings. The applications and supporting evidence vary by sample type and disease area.
Research applications include:
Changes in calprotectin concentrations have been investigated in relation to disease activity, treatment response, and relapse risk. Serial measurement may therefore provide researchers with a way to characterize changes in inflammatory activity over time and investigate how those changes relate to disease progression or response to treatment.
As research continues to expand our understanding of inflammation across diverse disease areas, calprotectin MRP8/14 remains a valuable biomarker for investigating innate immune activity. Continued research across different sample types and inflammatory conditions may further define its role in understanding disease activity, progression, and treatment response.
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