25-OH vitamin D is metabolized in the liver into 1,25 (OH)2 vitamin D. A deficiency of 1,25 (OH)2 vitamin D can be explained by metabolic disturbances, caused either by genetic enzyme defects (rare) or kidney malfunctions (more common). Even slightly impaired kidney function can lead to a decrease of 1,25 (OH)2 vitamin D concentration.

Since 1,25 (OH)2 vitamin D has important functions in calcium metabolism as well as supplementing secretion of parathyroid hormone from the parathyroid glands, increasing kidney malfunctioning leads to the development of renal osteopathy, which is characterized by osteomalacia and osteitis fibrosa.

The 1,25 (OH)2 Vitamin D ELISA Kit is intended for the quantitative determination of 1,25-dihydroxyvitamin D in serum and plasma.

Indications

• Aid in the identification of defective kidney functions, chronic kidney failure, or renal osteopathy
• Help monitor therapy with active vitamin D metabolites
• Aid in the identification of idiopathic hypercalciuria or hypercalcemia

The 1,25 (OH)2 Vitamin D ELISA Kit is for research use only. Not for use in diagnostic procedures.