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Immundiagnostik’s Calprotectin Mouse/Rat ELISA (S100A8/A9, MRP 8/14) was recently featured in a publication by Singh et al.

Publication Summary

Recent research has shown that 85% of all Parkinson’s disease patients experienced constipation years before showing signs of motor phenotypes. This finding has resulted in an urgent need to identify biomarkers that can indicate early Parkinson’s disease stages before the development of disease phenotypes.

The present study aims to show how DJ-1, a chaperone protein involved in Parkinson’s disease protection, and which is known to undergo genetic mutations which cause familial Parkinson’s disease, is also involved in shaping the gut microbiome.

Researchers used the IDK® Calprotectin Mouse/Rat ELISA (S100A8/A9, MRP 8/14) as part of the study. They concluded that metabolites and inflammation produced in the gut present plausible options for Parkinson’s disease detection biomarkers, because they may be involved in triggering inflammation which results in Parkinson’s disease pathology.

Read the full publication: DJ-1 (Park7) affects the gut microbiome, metabolites and the development of innate lymphoid cells (ILCs)

Biomarker Background: Calprotectin

Calprotectin is a calcium-binding protein secreted predominantly by neutrophils and monocytes. The heterocomplex consists of the two proteins, S100A8 (calgranulin A) and S100A9 (calgranulin B), also designated as MRP8 and MRP14, respectively.

Fecal S100A8/S100A9 is a marker for neoplastic and inflammatory gastrointestinal diseases. It is often difficult to distinguish between irritable bowel syndrome and chronic inflammatory bowel disease which may lead to extensive and unnecessary colonoscopy exams. The Calprotectin Mouse/Rat ELISA (S100A8/A9, MRP 8/14) allows for clear differentiation between the two groups and can indicate the degree of acute and gastrointestinal inflammation.

Learn More About the Calprotectin Mouse/Rat ELISA

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Featured Kit: Calprotectin Mouse/Rat ELISA (S100A8/A9, MRP 8/14)

  • Quantitative determination of Calprotectin/S100A8/S100A9/MRP (8/14) in stool, serum, plasma, urine, tissue extract, and cell culture supernatant
  • Measure acute inflammation and gastrointestinal inflammation degree
  • Research use only in the U.S.
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