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A study at Harokopio University in Athens, Greece aimed to investigate the connection between serum levels of vitamin D, folate, and cobalamin and IBD-related biomarkers using Immundiagnostik’s IDK Extract® Stool Preparation System. Deficiencies in these vitamins are commonly found in individuals with IBD.
A group of 87 individuals with either Crohn’s disease or ulcerative colitis participated in the study, and of those, 36.8%, 18.4%, and 5.7% were deficient in serum 25(OH)D, folate, and cobalamin, respectively. They also found positive associations between (a) serum 25(OH) Vitamin D with serum iron and (b) serum cobalamin with total bilirubin and direct bilirubin.
The researchers concluded that vitamin deficiencies are prevalent in people with IBD, and vitamins play a pivotal role in IBD severity and prognosis.
Read the full publication: Serum Vitamins D, B9, and B12 in Greek Patients with Inflammatory Bowel Diseases
Biomarker Background: Vitamin D
Vitamin D is an essential, fat-soluble vitamin produced in the body following exposure to sunlight or consumption of certain foods. It is bound in the blood to a binding protein (DBP) in its inactive form and must be activated by undergoing hydroxylation in the liver to become 25-hydroxyvitamin D (precursor vitamin D).
It is then further metabolized in the kidney to form 1,25-dihydroxyvitamin D (active vitamin D), which is the vitamin D metabolite with the highest biological activity and functions as a hormone (D-hormone). It regulates the uptake of calcium from the intestine, the mineralization of bones, the differentiation of osteoblasts as well as bone matrix synthesis. Furthermore, D-hormone influences neuro-muscular functions.
Recent studies have shown that active vitamin D levels are closely related to gut microbiome diversity, which suggests the gut microbiome’s role as a catalyst in the metabolism of precursor vitamin D to active vitamin D.
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The IDK Extract® Stool Sample Preparation System is FDA Class 1 Exempt. For In Vitro Diagnostic Use.
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Featured Kit: IDK Extract® Stool Sample Preparation System
- Allows for the determination of several parameters from a single stool sample
- Consistent, hygienic sample preparation
- Customized bulk quantities available