The IDK® Zonulin ELISA (Stool) is intended for the quantitative determination of zonulin family peptides (ZFP) in stool to assess intestinal permeability.

Zonulin is a tight-junction regulating protein in the digestive tract. Zonulin binds to a specific receptor on the surface of intestinal epithelia and triggers a cascade of biochemical events which induces tight junction disassembly and a subsequent permeability increase of the intestinal epithelia, allowing some substances to pass through and activate immune reactions.

An increased intestinal permeability, also known as 'leaky gut', is associated with metabolic syndrome, obesity, and several autoimmune, inflammatory, and neoplastic diseases. Based on the evidence, leaky gut plays a meaningful role in diseases such as multiple sclerosis, rheumatoid arthritis, asthma, and inflammatory bowel diseases.

The IDK® Zonulin ELISA (Stool) is Health Canada Licensed and developed by Immundiagnostik AG.

If your lab is testing at high volumes, the IDK® Zonulin ELISA (Stool) is also available in a customized bulk pack (20 plates).